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Trends in Molecular Medicine: Impact Factor and Future Directions
Introduction:
The field of molecular medicine is rapidly evolving, driven by breakthroughs in genomics, proteomics, and bioinformatics. Understanding the trends shaping this dynamic landscape is crucial for researchers, clinicians, and investors alike. This comprehensive article delves into the key trends impacting molecular medicine, examining their influence on impact factors of leading journals and forecasting future directions. We’ll explore emerging technologies, ethical considerations, and the evolving relationship between basic research and clinical application, providing a detailed overview for those seeking to navigate this exciting and rapidly changing field. This post will not only analyze the current state but also project the future trajectory of molecular medicine's impact and its influence on healthcare.
I. The Rising Impact Factor of Molecular Medicine Journals:
The impact factor, a metric reflecting the average number of citations received by articles published in a journal, serves as a benchmark for scientific influence. We are witnessing a significant increase in the impact factor of journals specializing in molecular medicine. This surge is directly correlated with several factors:
Technological Advancements: Next-generation sequencing (NGS), CRISPR-Cas9 gene editing, and advanced imaging techniques have fueled an explosion of research, resulting in a higher volume of high-impact publications. These technologies allow for deeper insights into disease mechanisms and the development of more targeted therapies.
Increased Funding: Governments and private investors are increasingly recognizing the transformative potential of molecular medicine. This increased funding translates into more research projects, leading to a larger number of high-quality publications and, consequently, a higher impact factor for relevant journals.
Interdisciplinary Collaboration: Molecular medicine thrives on collaboration between biologists, chemists, physicists, computer scientists, and clinicians. This interdisciplinary approach leads to more innovative research and publications with broader appeal, thereby increasing citation rates.
Focus on Translational Research: The emphasis on translating basic scientific discoveries into clinical applications is driving the impact factor upwards. Journals that prioritize translational studies showcasing tangible clinical benefits receive more attention and citations.
II. Emerging Trends Shaping Molecular Medicine:
Several emerging trends are poised to significantly impact the field in the coming years:
Personalized Medicine: The tailoring of medical treatments to individual patients based on their genetic makeup and other molecular characteristics is gaining significant traction. This approach promises more effective therapies with fewer side effects, driving the publication of numerous impactful studies.
Artificial Intelligence (AI) and Machine Learning (ML): AI and ML are revolutionizing drug discovery, diagnostics, and treatment planning. Algorithms can analyze vast datasets to identify potential drug targets, predict patient outcomes, and personalize treatment strategies, leading to highly cited publications in the field.
Liquid Biopsies: Analyzing circulating tumor DNA (ctDNA) and other biomarkers in blood samples offers a less invasive alternative to traditional tissue biopsies, accelerating research and publication of results with significant clinical implications.
Gene Therapy and Gene Editing: Advances in gene therapy and CRISPR-Cas9 technology are opening new avenues for treating previously incurable diseases. The groundbreaking nature of these advancements contributes significantly to the rising impact factor of relevant journals.
Immunotherapy: Harnessing the power of the immune system to fight cancer and other diseases continues to be a major focus, leading to significant advancements and high-impact publications.
III. Challenges and Ethical Considerations:
Despite the rapid progress, several challenges and ethical considerations need to be addressed:
Data Privacy and Security: The increasing reliance on big data raises concerns about patient privacy and data security. Robust data protection measures are crucial to maintain public trust and ensure ethical research practices.
Access and Equity: The high cost of personalized medicine and advanced therapies raises concerns about equitable access for all patients. Strategies to ensure affordable and accessible treatments are vital.
Regulatory Hurdles: The development and approval of new molecular therapies often face significant regulatory hurdles. Streamlining the regulatory process is essential to accelerate the translation of research findings into clinical practice.
Interpretation of Complex Data: The analysis and interpretation of complex genomic and other molecular data require specialized expertise. Developing standardized methodologies and training programs is crucial to ensure accurate and reliable results.
IV. Future Directions and Predictions:
The future of molecular medicine looks incredibly promising. We can anticipate:
Increased integration of AI and ML: AI and ML will play an even greater role in drug discovery, diagnostics, and treatment personalization.
Expansion of personalized medicine: Personalized medicine will become more widespread and accessible, leading to improved patient outcomes.
Development of novel therapeutic modalities: New therapeutic strategies targeting specific molecular pathways will emerge, leading to more effective treatments for various diseases.
Advancements in gene editing technologies: CRISPR-Cas9 and other gene editing technologies will continue to improve, leading to more precise and efficient gene therapies.
Greater emphasis on preventative medicine: Molecular medicine will play an increasingly important role in identifying individuals at high risk for disease and implementing preventative strategies.
V. Conclusion:
The trends in molecular medicine are undeniably positive, driving a significant increase in the impact factor of relevant journals. However, addressing the challenges and ethical considerations is crucial to ensure responsible innovation and equitable access to the benefits of these advancements. The future of molecular medicine is bright, promising a revolution in healthcare and improved quality of life for millions worldwide. Continuous research, collaboration, and ethical reflection are essential to harness the full potential of this transformative field.
Article Outline:
Title: Trends in Molecular Medicine: Impact Factor and Future Directions
Introduction: Hook the reader, overview of the article's content.
Chapter 1: The Rising Impact Factor of Molecular Medicine Journals (Technological advancements, increased funding, interdisciplinary collaboration, translational research).
Chapter 2: Emerging Trends Shaping Molecular Medicine (Personalized medicine, AI and ML, liquid biopsies, gene therapy, immunotherapy).
Chapter 3: Challenges and Ethical Considerations (Data privacy, access and equity, regulatory hurdles, data interpretation).
Chapter 4: Future Directions and Predictions (AI integration, personalized medicine expansion, novel therapies, gene editing advancements, preventative medicine).
Conclusion: Summarize key findings, emphasize the importance of ethical considerations, and offer a forward-looking perspective.
(The above sections constitute the detailed explanation of each point in the outline.)
FAQs:
1. What is the impact factor, and why is it important in molecular medicine? The impact factor is a measure of a journal's influence, reflecting the average number of citations received by its articles. A high impact factor indicates significant influence within the scientific community.
2. How have technological advancements influenced the impact factor of molecular medicine journals? Next-generation sequencing, CRISPR, and advanced imaging have generated a surge in high-impact research, boosting journal impact factors.
3. What are the ethical implications of personalized medicine? Personalized medicine raises concerns about data privacy, equitable access to costly treatments, and potential biases in algorithms.
4. How can AI and machine learning improve molecular medicine research? AI and ML can accelerate drug discovery, improve diagnostics, and personalize treatment strategies.
5. What are the challenges in translating basic research into clinical applications? Regulatory hurdles, cost considerations, and the complexity of translating basic findings into effective therapies present significant challenges.
6. What is the role of liquid biopsies in advancing molecular medicine? Liquid biopsies offer a less invasive way to analyze biomarkers, speeding up research and potentially improving diagnostics.
7. How can we ensure equitable access to the benefits of molecular medicine? Addressing cost barriers, improving healthcare infrastructure, and developing equitable distribution strategies are crucial.
8. What are the future prospects for gene editing technologies in treating diseases? Gene editing technologies like CRISPR hold great promise for treating genetic disorders, but safety and ethical concerns need to be addressed.
9. What role will preventative medicine play in the future of molecular medicine? Identifying individuals at high risk for diseases and implementing preventative strategies using molecular information will play a growing role in healthcare.
Related Articles:
1. The impact of CRISPR-Cas9 on the future of medicine: Explores the potential and challenges of CRISPR gene editing.
2. Personalized medicine: A revolution in healthcare: Discusses the principles, benefits, and challenges of personalized medicine.
3. AI and machine learning in drug discovery: Focuses on the application of AI in accelerating the development of new drugs.
4. Ethical considerations in genomic medicine: Analyzes the ethical dilemmas related to genomic data and its applications.
5. Liquid biopsies: A game-changer in cancer diagnostics: Discusses the advantages and limitations of liquid biopsies.
6. The rise of immunotherapy in cancer treatment: Reviews the progress and challenges in immunotherapy for cancer.
7. Big data and its implications for molecular medicine: Explores the opportunities and challenges of using big data in molecular medicine.
8. Regulatory pathways for novel molecular therapies: Details the regulatory processes for approving new molecular therapies.
9. The future of healthcare: A molecular perspective: Provides a broader outlook on the future of healthcare shaped by molecular medicine.
| trends in molecular medicine impact factor: New Trends in Biotechnology Nanjappa Shamanna Subba Rao, 1992 |
| trends in molecular medicine impact factor: Hot Topics in Cell Biology José Becerra, Leonor Santos-Ruiz, 2012 Summary This book is a definitive overview of the current 'state of the art' in cell biology. It is based on papers presented by leading researchers at the Spanish Society for Cell Biology's XIV Congress - a Congress that strives to achieve scientific excellence. Each participant was asked to prepare a 'mini review' of current and likely future development in their area of research. This book is based on those reviews. As such, it is therefore an analysis of current and future trends. Key Features Contains contributions from some of the world's leading researchers. The book is multidisciplinary, covering almost all topics in cell biology: from basic to applied cell biology, and a wide variety of models: from in vitro to vivo models, ranging from fish to rodents and humans. Each 'mini review' is an easy-read piece, describing the state of the art on a topic with clear language and in a summary format. The mini review format makes the book attractive not only to readers involved in cell biology research and teaching, but also professionals from other disciplines and students. The book takes a truly multidisciplinary approach; it covers a wide array of topics, and the book reflects how cell biology interacts with other disciplines The Editors Jose Becerra is Professor of Cell Biology at the University of Málaga (Spain) since 1989. He has been Dean Secretary, Vice-Dean and Dean of the Faculty of Sciences of Málaga, and is now the Head of the Department of Cell Biology, Genetics and Physiology. From 2001 to 2003 he was the Director of the Andalusian Laboratory of Biology (LAB, Seville), which was converted in the Andalusian Centre for Developmental Biology (CABD) under his term. He is a member of the Technical Committee of the National Stem Cell Bank since 2007, patron of the Board of Trustees of IMABIS Foundation (Mediterranean Institute for the Advance of Biotechnology and Health Research), coordinator of the Biomaterials and Tissue Engineering Area of the the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and member of the Direction Committee of the CIBER-BBN. Leonor Santos-Ruiz is Senior Researcher of the CIBER-BBN network at the Andalusian Center for Nanomedicine and Biotechnology (BIONAND). She started her career studying the cellular and molecular basis of lower vertebrates' amazing ability for tissue regeneration, with a special attention to bone and spinal cord repair. Readership Cell biology academics and researchers Contents Introduction Dynamics of cell compartments The intracellular trafficking Cell signaling Autophagy, apoptosis and cell homeostasis Cell biology of aging Plant cell biology Methods in cell biology Applied cell biology Cell biology of cancer Cell therapies and tissue engineering Neurodegeneration and cell biology Nanotechnology and cell biology: challenges and opportunities |
| trends in molecular medicine impact factor: The Psychology of Fake News Rainer Greifeneder, Mariela Jaffe, Eryn Newman, Norbert Schwarz, 2020-08-13 This volume examines the phenomenon of fake news by bringing together leading experts from different fields within psychology and related areas, and explores what has become a prominent feature of public discourse since the first Brexit referendum and the 2016 US election campaign. Dealing with misinformation is important in many areas of daily life, including politics, the marketplace, health communication, journalism, education, and science. In a general climate where facts and misinformation blur, and are intentionally blurred, this book asks what determines whether people accept and share (mis)information, and what can be done to counter misinformation? All three of these aspects need to be understood in the context of online social networks, which have fundamentally changed the way information is produced, consumed, and transmitted. The contributions within this volume summarize the most up-to-date empirical findings, theories, and applications and discuss cutting-edge ideas and future directions of interventions to counter fake news. Also providing guidance on how to handle misinformation in an age of “alternative facts”, this is a fascinating and vital reading for students and academics in psychology, communication, and political science and for professionals including policy makers and journalists. |
| trends in molecular medicine impact factor: Stem Cells Christine L. Mummery, Anja van de Stolpe, Bernard Roelen, Hans Clevers, 2014-05-23 The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on organs on chips and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. - Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy - Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice - Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice |
| trends in molecular medicine impact factor: Encyclopedia of Molecular Pharmacology Stefan Offermanns, W. Rosenthal, 2008-08-14 An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles. |
| trends in molecular medicine impact factor: Molecular Medicine R.J. Trent, 2005-04-29 Molecular medicine is the application of gene or DNA based knowledge to the modern practice of medicine. This book provides contemporary insights into how the genetic revolution is influencing medical thinking and practice on a broad front including clinical medicine, innovative therapies and forensic medicine. Extensively revised just after the completion of the Human Genome Project, it provides the latest in molecular medicine developments The only book in Molecular Medicine that has undergone three editions Current practice as well as future developments identified Extensive tables, well presented figures - resources for further understanding |
| trends in molecular medicine impact factor: Network Pharmacology Shao Li, 2021-09-29 This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of network target for the first time, which has become the core theory of network pharmacology. The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases. |
| trends in molecular medicine impact factor: How Tobacco Smoke Causes Disease United States. Public Health Service. Office of the Surgeon General, 2010 This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products. |
| trends in molecular medicine impact factor: The Physician Scientist's Career Guide Mark J. Eisenberg, 2010-10-14 The Physician Scientist’s Career Guide provides a complete guide to having a successful career as a Physician Scientist. Filled with first-hand experiences and practical advice, it guides readers through each step of this career path, from choosing a degree and training program, to navigating the tenure track, and through the intricacies of applying for and obtaining funding. The volume is unique in that it provides an overview of this entire career path, allowing readers to envision and prepare for their futures. The Physician Scientist’s Career Guide fulfills a unique and crucial need and will be an invaluable guide for medical students, fellows and newly appointed faculty members interested in a career in research. |
| trends in molecular medicine impact factor: Current Trends in Cancer Research , 1964 |
| trends in molecular medicine impact factor: Aminoff's Neurology and General Medicine Michael J. Aminoff, S. Andrew Josephson, 2014-02-18 Aminoff's Neurology and General Medicine is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering metastatic disease, bladder disease, psychogenic disorders, dementia, and pre-operative and post-operative care of patients with neurologic disorders, this new edition will again be the go-to reference for both neurologists and general practitioners. - The standard authoritative reference detailing the relationship between neurology and general medicine - 100% revised and updated with several new chapters - Well illustrated, with most illustrations in full color |
| trends in molecular medicine impact factor: Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2011 Edition , 2012-01-09 Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Medical Microbiology, Mycology, Virology, and Molecular Medicine. The editors have built Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medical Microbiology, Mycology, Virology, and Molecular Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| trends in molecular medicine impact factor: Molecular Biology of the Cell , 2002 |
| trends in molecular medicine impact factor: Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2013 Edition , 2013-05-01 Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Medical Microbiology. The editors have built Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medical Microbiology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Medical Microbiology, Mycology, Virology, and Molecular Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| trends in molecular medicine impact factor: Improving Healthcare Quality in Europe Characteristics, Effectiveness and Implementation of Different Strategies OECD, World Health Organization, 2019-10-17 This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies. |
| trends in molecular medicine impact factor: List of Journals Indexed in Index Medicus National Library of Medicine (U.S.), 2004 Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus. |
| trends in molecular medicine impact factor: Stem Cells Mariusz Z. Ratajczak, 2020-01-02 Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field. |
| trends in molecular medicine impact factor: List of Journals Indexed for MEDLINE , 2005 |
| trends in molecular medicine impact factor: Fostering Integrity in Research National Academies of Sciences, Engineering, and Medicine, Policy and Global Affairs, Committee on Science, Engineering, Medicine, and Public Policy, Committee on Responsible Science, 2018-01-13 The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support †or distort †practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices. |
| trends in molecular medicine impact factor: Index Medicus , 2004 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| trends in molecular medicine impact factor: Genomic Medicine Dhavendra Kumar, Charis Eng, 2014-10-15 Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008. |
| trends in molecular medicine impact factor: Pain Management and the Opioid Epidemic National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse, 2017-09-28 Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring. |
| trends in molecular medicine impact factor: Molecular Analyses Scott Orland Rogers, 2022-07-11 DNA and RNA extraction methods from a variety of tissues and samples are now routine, including extraction from single cells. Many methods are now automated. Sequencing efficiency has reached the point where it is now possible to obtain gigabases of data, both quickly and inexpensively. Such methods permit the identification of gene versions, including those associated with disease (e.g. small nucleotide polymorphism analyses, or SNPs). The general public as well as clinicians can now access a wide variety of literature on the molecular bases of diseases, allowing them to better assess disease risks and treatments. This volume concentrates on medically-focused methods, and therefore the major audience will be medical professionals, students, and those involved in medically-related research endeavors. There are also papers in this volume dealing specifically with methods developed to analyze large sequence data sets. Many methods reviewed herein are more broadly applicable to other fields in biology, chemistry, bioinformatics, and bioengineering, and are intended for a broad readership. Key Features Summarizes nucleic acid extractions from a wide variety of tissues and cells Describes processes of nucleic acid preservation Reviews forensic sampling, detection of nucleic acids, and delivery of nucleic acids to multicellular organisms Provides essential guidance for sequencing, sequence analysis, database searches, and phylogenetic analyses Includes additional methods useful for analysis of nucleic acids and proteins Related Titles DeSalle, et al. Phylogenomics: A Primer (ISBN 978-0-3670-2849-7). Jennings, W. B. Phylogenomic Data Acquisition: Principles and Practice (ISBN 978-0-3678-6980-9). Wang, X. Next-Generation Sequencing Data Analysis (ISBN 978-1-4822-1788-9) Sung, W.-K. Algorithms for Next-Generation Sequencing (ISBN 978-0-3676-5797-0) |
| trends in molecular medicine impact factor: Cumulated Index Medicus , 1999 |
| trends in molecular medicine impact factor: Sleep Disorders and Sleep Deprivation Institute of Medicine, Board on Health Sciences Policy, Committee on Sleep Medicine and Research, 2006-10-13 Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems. |
| trends in molecular medicine impact factor: Herbal Medicine Iris F. F. Benzie, Sissi Wachtel-Galor, 2011-03-28 The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef |
| trends in molecular medicine impact factor: Hepatobiliary Cancers: Translational Advances and Molecular Medicine , 2022-08-10 Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. - Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity - Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target - Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers |
| trends in molecular medicine impact factor: Oral Mucosal Immunity and Microbiome Georgios N. Belibasakis, George Hajishengallis, Nagihan Bostanci, Michael A. Curtis, 2019-11-15 The first International Conference on Oral Mucosal Immunity and Microbiome (OMIM) aimed to highlight cutting-edge basic and translational research from an oral immunological and microbiological perspective. Oral diseases with a microbial etiology are the most prevalent chronic diseases of humans. Whilst not life-threatening, they can significantly compromise quality of life, are associated with increased risk for certain systemic diseases, and pose heavy financial burdens to national health systems. Hence, periodontal and peri-implant diseases, dental caries, root canal infections and mucosal infections are significant global public health problems. In this book global experts summarize and discuss the latest progress made in oral mucosal immunity and the oral microbiome. Target audience is basic and/or translational researchers with expertise in host immunity and microbiome research, and interest in oral health and disease. This volume provides a much needed quantum leap in the field, by joining forces to address gaps at the oral mucosal immunity-microbiome cross-talk. |
| trends in molecular medicine impact factor: The Nanotechnology Revolution Dale A. Stirling, 2018-01-17 Nanotechnology is changing the world in a very big way, but at the atomic and sub-atomic level. Although the roots of nanotechnology can be traced back to more than a century ago, the last three decades have witnessed an explosion of nano-based technologies and products. This reference work examines the history, current status, and future directions of nanotechnology through an exhaustive search of the technical and scientific literature. The more than 4000 bibliographic citations it includes are carefully organized into core subject areas, and a geographic and subject index allows readers to quickly locate documents of interest. Although a sense of the global reach and interest in nanotechnology can be gleaned from the reference sections of countless journal articles, conference papers, and books, this is the only reference work providing an in-depth global perspective that is ready-made for nanotechnology professionals and those interested in learning more about all things nanotechnology. Despite the abundance of online resources, there is still an urgent need for well-researched, well-presented, concise, and thematically organized reference works. Instead of relying on wiki pages, citation aggregators, and related websites, the author searched the databases and databanks of scholarly literature search providers such as EBSCO, ProQuest, PUBMED, STN International, and Thomson Reuters. In addition, he used select serials-related databases to account for pertinent documents from countries in which English is not the primary national language (i.e., China Online Journals, e-periodica, J-STAGE, and SciELO Brazil among others). |
| trends in molecular medicine impact factor: Our Society Journal , 1885 |
| trends in molecular medicine impact factor: Lipid Mediators Fiona M. Cunningham, 1994 This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science. |
| trends in molecular medicine impact factor: Intestinal Stem Cell Niche , 2018-04-24 Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication |
| trends in molecular medicine impact factor: Biological Variation Callum G. Fraser, 2001 |
| trends in molecular medicine impact factor: Not in Our Genes Richard Lewontin, Steven Rose, Leon J. Kamin, 2017 Three eminent scientists analyze the scientific, social, and political roots of biological determinism. |
| trends in molecular medicine impact factor: Modified Nucleic Acids Kazuhiko Nakatani, Yitzhak Tor, 2016-04-04 This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes. |
| trends in molecular medicine impact factor: Improving Diagnosis in Health Care National Academies of Sciences, Engineering, and Medicine, Institute of Medicine, Board on Health Care Services, Committee on Diagnostic Error in Health Care, 2015-12-29 Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety. |
| trends in molecular medicine impact factor: Single-particle Cryo-EM of Biological Macromolecules GLAESER, Eva Nogales, Wah Chiu, 2021-05-19 This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book, provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results. Key features Written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM Provides a comprehensive, accessible and authoritative introduction to the field of high-resolution structure analysis by single-article cryo-EM Covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results Authors of individual sections of this book have been recruited from among the most authoritative leaders in each topic |
| trends in molecular medicine impact factor: The Heterogeneity of Cancer Metabolism Anne Le, 2021-05-20 This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. |
| trends in molecular medicine impact factor: Environmental Epigenetics L. Joseph Su, Tung-chin Chiang, 2015-05-18 This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. |
| trends in molecular medicine impact factor: Sinusoidal Cells in Liver Diseases Jordi Gracia-Sancho, 2024-04-09 Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure. - Provides a comprehensive update on the role of sinusoidal cells in acute and chronic liver diseases - Covers our current understanding of the role of sinusoidal cells as therapeutic targets to improve liver diseases - Presents the latest research in the development of novel biomarkers of liver diseases that derive from sinusoidal cells |
