Impact Factor Methods Mol Biol

Impact Factor Methods in Molecular Biology: A Comprehensive Guide

Introduction:

The impact factor (IF) has become a ubiquitous metric in assessing the relative importance and influence of scientific journals, particularly within the field of molecular biology. Understanding how impact factors are calculated and the implications of their use is crucial for researchers, editors, and anyone navigating the complex landscape of scientific publishing. This comprehensive guide delves into the methods behind calculating impact factors, their strengths and weaknesses, alternatives to IF, and their overall significance in the molecular biology research community. We will explore the nuances of IF, debunking common misconceptions and providing a clear picture of its role in evaluating research output. This isn't just a surface-level overview; we'll dissect the methodology, consider its limitations, and offer insights into navigating the implications of IF within your own research journey.

1. Understanding the Impact Factor: A Definition and its Components

The impact factor, at its core, represents the average number of citations received per published article in a journal over a specific period (typically two years). It's calculated by dividing the number of citations received by articles published in the journal during the two preceding years by the total number of citable articles published in those same two years. This seemingly simple formula belies a complex reality, as the definition itself necessitates careful consideration of what constitutes a "citable article" and the potential for bias in citation practices. We’ll explore these nuances later.

2. The Calculation Methodology: Dissecting the Formula and its Limitations

The calculation itself, while straightforward in theory, requires rigorous data collection and careful consideration of several factors:

Identifying Citable Articles: Not all articles published are considered citable. Editorials, letters to the editor, and other non-research articles are generally excluded. Defining what constitutes a “citable article” can be surprisingly subjective and influence the final IF.
Citation Databases: The specific citation database used (e.g., Web of Science, Scopus) significantly impacts the final IF. Different databases utilize different indexing methods, leading to variations in the number of citations recorded. This database dependence introduces a crucial source of variability.
Citation Practices: The culture of citation within a specific field can influence the IF. Some fields are more prone to self-citation or citation inflation, skewing the results. Moreover, the time lag between publication and citation can also affect the IF, particularly for newer journals.
Journal Scope and Specialization: The IF is heavily influenced by the journal's scope and specialization. A highly specialized journal might have a lower IF than a more generalist one, even if the quality of its research is equally high. This makes comparing IFs across vastly different journals problematic.

3. Alternative Metrics Beyond the Impact Factor

While the IF remains prevalent, its limitations have prompted the development of alternative metrics. These include:

Article-Level Metrics: These focus on individual article performance, such as altmetrics (measuring online attention and usage), citation counts per article, and downloads. These offer a more granular assessment compared to journal-level metrics like the IF.
h-index: This index considers both the number of publications and the number of citations received per publication, offering a more nuanced picture of a researcher's impact.
Source Normalized Impact per Paper (SNIP) and SCImago Journal Rank (SJR): These metrics attempt to correct for field-specific citation biases. SNIP and SJR normalize citation counts relative to the average citation count in a specific field, offering a more accurate comparison across disciplines.

4. The Impact Factor in Molecular Biology: Specific Considerations

The field of molecular biology, with its rapid advancements and highly interconnected research areas, presents unique challenges and considerations regarding the IF. The high citation rates in certain subfields can artificially inflate IFs, making comparisons within the discipline itself sometimes difficult. Furthermore, the rapid dissemination of research through preprint servers and online databases complicates traditional citation tracking methods.

5. Ethical Considerations and Misinterpretations of the Impact Factor

The IF, while useful as a metric, is often misused and misinterpreted. Over-reliance on IF can lead to:

Publication Bias: Researchers may prioritize submitting to high-IF journals, even if the research is not ideally suited to that specific journal. This can lead to a skewed representation of the research landscape.
Predatory Journals: Some publishers exploit the emphasis on IF, creating predatory journals that prioritize publication fees over quality control.
Gaming the System: Researchers may engage in practices aimed at artificially inflating their citations, compromising the integrity of the metric.


Book Outline: "Navigating the Impact Factor in Molecular Biology Research"

Introduction: Defining the impact factor, its significance in molecular biology, and the scope of the book.
Chapter 1: Understanding Impact Factor Calculation: A detailed explanation of the methodology, including the identification of citable articles, the role of citation databases, and potential biases.
Chapter 2: Limitations and Alternatives to the Impact Factor: Critical analysis of the IF's limitations, exploring alternative metrics such as article-level metrics, the h-index, SNIP, and SJR.
Chapter 3: The Impact Factor in Molecular Biology Research: Specific challenges and considerations related to the field, including rapid advancements, interconnectivity, and preprint servers.
Chapter 4: Ethical Considerations and Responsible Use of the Impact Factor: Discussing ethical implications, publication bias, predatory journals, and practices that manipulate the IF.
Chapter 5: Practical Strategies for Researchers: Guidance for researchers on navigating the IF landscape, choosing appropriate journals, and avoiding common pitfalls.
Conclusion: Summarizing key takeaways, emphasizing responsible interpretation of IF, and promoting a balanced approach to scientific evaluation.



(Detailed explanation of each chapter will be provided in the main article. Due to space constraints, it’s omitted from this outline structure.)


9 Unique FAQs:

1. Q: Is a high impact factor always indicative of high-quality research? A: No, a high impact factor doesn't guarantee high-quality research. Several factors can inflate an IF, and it's crucial to consider the journal's scope and the specific research area.

2. Q: How often is the impact factor calculated? A: The impact factor is typically calculated annually, using citation data from the two preceding years.

3. Q: What are some alternative metrics to the impact factor? A: Alternatives include article-level metrics (downloads, altmetrics), the h-index, SNIP, and SJR.

4. Q: Can impact factors be manipulated? A: Yes, unfortunately, there are various ways to potentially manipulate the impact factor, including self-citation and citation rings.

5. Q: How does the impact factor affect a researcher's career? A: While not always the sole determinant, a researcher’s publications in high-impact journals can positively influence their career progression, grant applications, and overall recognition.

6. Q: What is the difference between Web of Science and Scopus impact factors? A: They use different indexing methods and databases, leading to varying impact factor calculations for the same journal.

7. Q: Are there any journals specifically focused on the impact factor's methodology? A: While not entirely dedicated to the impact factor's methodology, many scholarly communication journals publish articles discussing its limitations, alternatives, and ethical considerations.

8. Q: Is the impact factor a useful metric for early-career researchers? A: While valuable for assessing a journal's prominence, early-career researchers should focus on the quality and originality of their research, not solely on the journal's impact factor.

9. Q: How can I avoid predatory journals that misuse the impact factor? A: Research the journal thoroughly, check for transparent publication practices, and avoid journals that primarily focus on fast publication and high fees.



9 Related Articles:

1. "The Limitations of the Impact Factor in Evaluating Research Quality": This article critically examines the drawbacks of using IF as a sole measure of research quality.

2. "Beyond the Impact Factor: Exploring Alternative Metrics for Assessing Scientific Journals": This piece delves into the various alternative metrics and their advantages over the IF.

3. "Impact Factor and Publication Bias: A Critical Review": This article analyzes the relationship between IF and publication bias in different scientific fields.

4. "The Role of Preprint Servers in Challenging Traditional Citation Metrics": Explores how the rise of preprints affects citation counts and traditional IF calculations.

5. "Evaluating the Impact Factor in Molecular Biology: Field-Specific Considerations": A focused examination of the specific challenges and nuances of using IF in the field of molecular biology.

6. "Predatory Publishing and the Misuse of Impact Factor": This article details the practices of predatory journals and how they leverage the IF for deceptive purposes.

7. "The Impact of Impact Factor on Early-Career Researchers": Explores the influence of IF on the career paths and decision-making of young scientists.

8. "A Comparative Analysis of Web of Science and Scopus Impact Factors": A comparative study focusing on the differences in methodologies and results between these two major citation databases.

9. "Developing a More Holistic Approach to Journal Evaluation": This article argues for a multi-faceted approach to assessing journals, moving beyond sole reliance on the impact factor.


  impact factor methods mol biol: Current Protocols in Molecular Biology ,
  impact factor methods mol biol: Basic Methods in Molecular Biology Leonard G. Davis, Mark D. Dibner, James F. Battey, 1992 The new edition of this popular book emphasizes the decisions that need to be made to select one procedure over another.
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  impact factor methods mol biol: Data Mining in Clinical Medicine Carlos Fernández Llatas, Juan Miguel García-Gómez, 2014-11-24 This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.
  impact factor methods mol biol: Molecular Biology of the Cell , 2002
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  impact factor methods mol biol: Handbook of ELISPOT Alexander E. Kalyuzhny, 2008-02-02 In this first book dedicated entirely to the ELISPOT, a critical enzyme-linked immunospot assay used widely in biomedical research, recognized experts with first-hand experience detail how to design, perform, and analyze these assays. The readily reproducible techniques they provide cover a wide variety of topics, including the use of membrane-backed plates, the standardization and validation procedures, the removal of cells from ELISPOT plates, cell separation techniques, and the quantification of ELISPOT data. There are also numerous ELISPOT applications involving animal models, human cells, measles, multiple sclerosis, immune responses, multicytokine detection systems, and immunocytochemistry. Highlights include dual-color and multiplex ELISPOT assays, use of the ELISPOT assay on feline lymphocytes, standardization of the ELISPOT procedure, and combining the ELISPOT assay with immunohistochemistry.
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  impact factor methods mol biol: Data Analysis in Molecular Biology and Evolution Xuhua Xia, 2007-05-08 Data Analysis in Molecular Biology and Evolution introduces biologists to DAMBE, a proprietary, user-friendly computer program for molecular data analysis. The unique combination of this book and software will allow biologists not only to understand the rationale behind a variety of computational tools in molecular biology and evolution, but also to gain instant access to these tools for use in their laboratories. Data Analysis in Molecular Biology and Evolution serves as an excellent resource for advanced level undergraduates or graduates as well as for professionals working in the field.
  impact factor methods mol biol: Guide to Yeast Genetics and Molecular Biology Christine Guthrie, Gerald R. Fink, 1991-01-28 Guide to Yeast Genetics and Molecular Biology presents, for the first time, a comprehensive compilation of the protocols and procedures that have made Saccharomyces cerevisiae such a facile system for all researchers in molecular and cell biology. Whether you are an established yeast biologist or a newcomer to the field, this volume contains all the up-to-date methods you will need to study Your Favorite Gene in yeast. Basic Methods in Yeast Genetics**Physical and genetic mapping**Making and recovering mutants**Cloning and Recombinant DNA Methods**High-efficiency transformation**Preparation of yeast artificial chromosome vectors**Basic Methods of Cell Biology**Immunomicroscopy**Protein targeting assays**Biochemistry of Gene Expression**Vectors for regulated expression**Isolation of labeled and unlabeled DNA, RNA, and protein
  impact factor methods mol biol: Plant Stress Tolerance Ramanjulu Sunkar,
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  impact factor methods mol biol: Methods in Microbiology , 2021-07-07 The book Methods in Silkworm Microbiology is the first ever publication that provides in-depth reviews on the latest progresses about silkworm –pathogen interactions, diseases and management practices for sustainable development of sericulture. Different molecular and immunodiagnostic methods for the detection of pathogens have been comprehensively addressed. Most recent advancements on the role of Micro RNAs in silkworm and pathogen interactions are provided with suitable illustrations. Recent technological advances and emerging trends in exploring silkworm gut microbial communities towards translation research, particularly to understand microbiome functions have been highlighted. Information on various immune mechanisms of silkworm against invading pathogens is summarized. The book further highlights the silkworm gut microbiota as a potential source for biotechnological applications. - Provide comprehensive reviews and valuable methods from the selected experts on the topic Methods in silkworm microbiology/pathology - Provides latest information on application of genomics and transcriptomics to decipher silkworm gut microbial communities. Different molecular and immunodiagnostic methods for the detection of pathogens have been comprehensively addressed - Provides up to date information on silkworm-pathogen interactions, different silkworm diseases and immune mechanisms
  impact factor methods mol biol: Protein Kinase Factsbook D. Grahame Hardie, 1995 How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 130 entries on members of the family from vertebrates, Drosophila , higher plants, yeasts, nematodes, slime moulds and other organisms. Key Features* Subunit structure and isoforms* Genetics* Sequence database accession numbers* Domain structures* Amino acid sequences* Homologues in other species* Patterns of expression* Physiological substrates and specificity determinants* Assays* Enzyme activators and inhibitors* References.
  impact factor methods mol biol: Embryonic Stem Cell Protocols Kursad Turksen, 2008-02-04 Now in two volumes, this completely updated and expanded edition of Embryonic Stem Cells: Methods and Protocols provides a diverse collection of readily reproducible cellular and molecular protocols for the manipulation of nonhuman embryonic stem cells. Volume one, Embryonic Stem Cell Protocols: Isolation and Characterization, Second Edition, provides a diverse collection of readily reproducible cellular and molecular protocols for the isolation, maintenance, and characterization of embryonic stem cells. The second volume, Embryonic Stem Cell Protocols: Differentiation Models, Second Edition, covers state-of-the-art methods for deriving many types of differentiating cells from ES cells. Together, the two volumes illuminate for both novices and experts our current understanding of the biology of embryonic stem cells and their utility in normal tissue homeostasis and regenerative medicine applications.
  impact factor methods mol biol: Index Medicus , 2004 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
  impact factor methods mol biol: Opportunities in Biology National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Biology, Committee on Research Opportunities in Biology, 1989-01-01 Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€recombinant DNA, scanning tunneling microscopes, and moreâ€are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€for funding, effective information systems, and other supportâ€of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.
  impact factor methods mol biol: Axonal Transport Alessio Vagnoni, 2022-08-11 This volume covers a wide range of model systems from invertebrate to humans and in vitro and in vivo. Chapters detail methods on squid, aplysia, xenopus, mouse in vivo, ex vivo, rodent primary neurons, human-derived neurons, zebrafish, drosophila in vivo, primary neurons, c. elegans, and in vitro reconstitution assays.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Axonal Transport: Methods and Protocols aims to further our understanding of the trafficking of cellular components in the nervous system leading to the advancement of basic knowledge that underlines the cell biology of the neuron. The chapters “ Live imaging of RNA Transport and Translation in Xenopus Retinal Axons, Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons, Assessment of Mitochondrial Trafficking as A Surrogate of Fast Axonal Transport in Human Induced Pluripotent Stem Cell Derived Spinal Motor Neurons, Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport, and In vitro Reconstitution of Kinesin-Based, Axonal mRNA Transport” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com
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  impact factor methods mol biol: Docking Screens for Drug Discovery Walter Filgueira de Azevedo Jr., 2019-08-27 This book focuses on recent developments in docking simulations for target proteins with chapters on specific techniques or applications for docking simulations, including the major docking programs. Additionally, the volume explores the scoring functions developed for the analysis of docking results and to predict ligand-binding affinity as well as the importance of docking simulations for the initial stages of drug discovery. Written for the highly successful Methods in Molecular Biology series, this collection presents the kind of detail and key implementation advice to ensure successful results. Authoritative and practical, Docking Screens for Drug Discovery aims to serve those interested in molecular docking simulation and also in the application of these methodologies for drug discovery.
  impact factor methods mol biol: Pre-Clinical Models Paul C. Guest, 2019-02-04 This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models in a number of medical areas, including metabolic disorders, longevity, cancer, heart disease and psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context of specific disease or therapeutic areas.
  impact factor methods mol biol: Chemical Protein Synthesis Xuechen Li, 2022-06-29 This volume provides updated protocols for chemical protein synthesis. Chapters guide readers through development methods, strategies, and applications of protein chemical synthesis. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Chemical Protein Synthesis aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
  impact factor methods mol biol: Protein Engineering and Design Paul R. Carey, 1996-06-21 The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. - Introduces and defines the techniques involved in protein engineering and design - Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides
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  impact factor methods mol biol: Molecular Biology and Pathogenicity of Mycoplasmas Shmuel Razin, Richard Herrmann, 2007-05-08 was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology.
  impact factor methods mol biol: Viscoelastic Properties of Polymers John D. Ferry, 1980-09-16 Viscoelastic behavior reflects the combined viscous and elastic responses, under mechanical stress, of materials which are intermediate between liquids and solids in character. Polymers the basic materials of the rubber and plastic industries and important to the textile, petroleum, automobile, paper, and pharmaceutical industries as well exhibit viscoelasticity to a pronounced degree. Their viscoelastic properties determine the mechanical performance of the final products of these industries, and also the success of processing methods at intermediate stages of production. Viscoelastic Properties of Polymers examines, in detail, the effects of the many variables on which the basic viscoelastic properties depend. These include temperature, pressure, and time; polymer chemical composition, molecular weight and weight distribution, branching and crystallinity; dilution with solvents or plasticizers; and mixture with other materials to form composite systems. With guidance by molecular theory, the dependence of viscoelastic properties on these variables can be simplified by introducing certain ancillary concepts such as the fractional free volume, the monomeric friction coefficient, and the spacing between entanglement loci, to provide a qualitative understanding and in many cases a quantitative prediction of how to achieve desired results. The phenomenological theory of viscoelasticity which permits interrelation of the results of different types of experiments is presented first, with many useful approximation procedures for calculations given. A wide variety of experimental methods is then described, with critical evaluation of their applicability to polymeric materials of different consistencies and in different regions of the time scale (or, for oscillating deformations, the frequency scale). A review of the present state of molecular theory follows, so that viscoelasticity can be related to the motions of flexible polymer molecules and their entanglements and network junctions. The dependence of viscoestic properties on temperature and pressure, and its descriptions using reduced variables, are discussed in detail. Several chapters are then devoted to the dependence of viscoelastic properties on chemical composition, molecular weight, presence of diluents, and other features, for several characteristic classes of polymer materials. Finally, a few examples are given to illustrate the many potential applications of these principles to practical problems in the processing and use of rubbers, plastics, and fibers, and in the control of vibration and noise. The third edition has been brought up to date to reflect the important developments, in a decade of exceptionally active research, which have led to a wider use of polymers, and a wider recognition of the importance and range of application of viscoelastic properties. Additional data have been incorporated, and the book s chapters on dilute solutions, theory of undiluted polymers, plateau and terminal zones, cross-linked polymers, and concentrated solutions have been extensively rewritten to take into account new theories and new experimental results. Technical managers and research workers in the wide range of industries in which polymers play an important role will find that the book provides basic information for practical applications, and graduate students in chemistry and engineering will find, in its illustrations with real data and real numbers, an accessible introduction to the principles of viscoelasticity.
  impact factor methods mol biol: Biological & Agricultural Index , 1981
  impact factor methods mol biol: Molecular Ecology and Evolution: Approaches and Applications B. Schierwater, B. Streit, G.P. Wagner, R. DeSalle, 2013-06-29 The past 25 years have witnessed a revolution in the way ecologists and evolutionary biologists approach their disciplines. Modern molecular techniques are now reshaping the spectrum of questions that can be addressed while studying the mechanisms and consequences of the ecology and evolution of living organisms. Molecular Ecology and Evolution: Approaches and Applications describes, from a molecular perspective, several methodological and technical approaches used in the fields of ecology, evolution, population biology, molecular systematics, conservation genetics, and development. Modern techniques are introduced, and older, more classic ones refined. The advantages, limitations, and potentials of each are discussed in detail, and thereby illustrate the widening range of cross-field research and applications which this modern technology is stimulating. This book will serve as an important textbook for graduate and advanced undergraduate students, and as a key reference work for researchers
  impact factor methods mol biol: Current Protocols in Bioinformatics Andreas D. Baxevanis, 2003 Current Protocols in Bioinformatics is the only publication that responds to the need for both a current and updateable source of bioinformatics methodology. This unique publication assures that you have access to a full range of bioinformatics protocols written by globally-recognized experts in the field, and that these proto-cols are updated and revised as new developments and innovations occur.
  impact factor methods mol biol: Current Protocols in Chemical Biology Adam P. Arkin, 2009-09-22
  impact factor methods mol biol: Atlas of Protein Sequence and Structure , 1973
  impact factor methods mol biol: Serum/Plasma Proteomics Richard J Simpson, David W Greening, 2016-05-01 Blood science has become a cornerstone of multiple disciplines. This book, contributed to by leading experts in the field, provides a comprehensive resource of protocols for areas, pre-analytical through to analytical, of plasma and serum proteomics.
  impact factor methods mol biol: Cumulated Index Medicus , 1996
  impact factor methods mol biol: Tropical Diseases Bulletin , 1958
  impact factor methods mol biol: Henry's Clinical Diagnosis and Management by Laboratory Methods: First South Asia Edition_E-book Richard A. McPherson, 2016-08-31 To interpret the laboratory results. To distinguish the normal from the abnormal and to understand the merits and demerits of the assays under study. The book attempts to train a laboratory medicine student to achievesound knowledge of analytical methods and quality control practices, tointerpret the laboratory results, to distinguish the normal from the abnormaland to understand the merits and demerits of the assays under study.
  impact factor methods mol biol: DNA Methylation Protocols Jörg Tost, 2018-08-30 This third edition volume expands on the previous editions by providing a comprehensive update on the available technologies required to successfully perform DNA methylation analysis. The different technologies discussed in this book analyze the global DNA methylation contents, comprehensive analyses using various NGS based methods for genome-wide DNA methylation analysis, along with precise quantification of DNA methylation levels on single CpG positions. The chapters in this book are divided into 7 parts: an introduction to the field along with tips on study design and data analysis; global DNA methylation levels; genome-wide DNA methylation analysis; highly multiplexed target regions; locus-specific DNA methylation analysis; DNA methylation analysis of specific biological samples; and hydroxymethylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, DNA Methylation Protocols, Third Edition is a valuable resource for postdoctoral investigators and research scientists who work with different aspects of genetics, and cellular and molecular biology, as well as clinicians who are involved in diagnostics or treatment of diseases with epigenetic components.
  impact factor methods mol biol: Expression, Purification, and Structural Biology of Membrane Proteins Camilo Perez, Timm Maier, 2021-03-14 This book collects up-to-date advanced protocols and advice from leading experts in the area of membrane protein biology that can be applied to structural and functional studies of any membrane protein system. The contents explore methods for cloning and expression of membrane proteins and membrane protein complexes in prokaryotic and eukaryotic systems, approaches for protein purification, nanobody applications, as well as biophysical characterization and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Expression, Purification, and Structure Biology of Membrane Proteins serves to guide and encourage young researchers and newcomers to the field to tackle bold new studies on membrane proteins. Chapter 11 is available open access under a CC-BY 4.0 license via link.springer.com.