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Unlocking the Secrets of Aldolase Quest: A Comprehensive Guide
Introduction:
Are you intrigued by the fascinating world of enzymes and their critical roles in cellular processes? Have you ever wondered about the specific function of aldolase and its importance in metabolic pathways? This comprehensive guide delves deep into the intricacies of "Aldolase Quest," exploring its significance in various fields, from biochemistry research to diagnostic applications. We’ll uncover the underlying mechanisms of aldolase activity, examine its clinical relevance, and discuss the ongoing research pushing the boundaries of our understanding. Prepare to embark on a journey into the heart of cellular metabolism and discover the compelling story of aldolase. This post offers a thorough exploration of aldolase, covering its structure, function, clinical significance, and future research directions, making it a valuable resource for students, researchers, and healthcare professionals alike.
Understanding Aldolase: Structure, Function, and Isozymes
Aldolase is a crucial enzyme primarily involved in glycolysis, the metabolic pathway responsible for breaking down glucose to produce energy. Its primary function is to catalyze the reversible cleavage of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is a key step in glycolysis, serving as a critical branch point in the pathway.
Several aldolase isozymes exist, each with specific tissue distribution and catalytic properties. The most commonly studied are aldolase A, B, and C.
Aldolase A: Predominantly found in muscle tissue, this isozyme is crucial for energy production during muscle contraction.
Aldolase B: Primarily located in the liver, it plays a pivotal role in hepatic glucose metabolism.
Aldolase C: Found in the brain, this isozyme is important for neuronal energy production.
Understanding the structural differences between these isozymes allows for a deeper comprehension of their specific roles and regulatory mechanisms. These subtle variations in amino acid sequences lead to distinct catalytic efficiencies and substrate affinities. Research into these structural differences continues to provide crucial insights into enzyme specificity and regulation.
Aldolase in Clinical Diagnostics: A Valuable Biomarker
Elevated levels of aldolase in the blood can serve as a valuable biomarker for various diseases and conditions. Muscle damage, caused by conditions such as muscular dystrophy, rhabdomyolysis, and trauma, often leads to the release of aldolase into the bloodstream. Measuring aldolase levels can aid in diagnosing and monitoring these conditions.
Similarly, elevated aldolase levels can be observed in hepatic diseases, reflecting liver cell damage. The specific isozyme elevated can sometimes provide clues about the location and nature of the tissue damage. However, it's crucial to remember that aldolase levels alone are not sufficient for definitive diagnosis. They should be interpreted in conjunction with other clinical findings and laboratory tests.
Aldolase in Research: Current Trends and Future Directions
Research on aldolase continues to expand our understanding of its role in various metabolic processes and its potential therapeutic applications. Current research focuses on several key areas:
Enzyme Engineering: Researchers are exploring ways to engineer aldolase to enhance its catalytic efficiency and expand its substrate specificity. This could have significant implications for the production of valuable biomolecules and pharmaceuticals.
Drug Development: Aldolase is being investigated as a potential drug target for various diseases. Modulating aldolase activity could offer new therapeutic strategies for conditions such as cancer and metabolic disorders.
Diagnostic Applications: Ongoing research aims to refine the use of aldolase as a diagnostic biomarker, improving its sensitivity and specificity for various diseases. Development of more accurate and rapid diagnostic tests is a priority.
The Significance of "Aldolase Quest" in the Broader Context
The term "Aldolase Quest," while not a formally recognized scientific term, aptly captures the ongoing efforts to unravel the mysteries surrounding this vital enzyme. It symbolizes the continuous investigation into its structure, function, and clinical relevance. This quest encompasses not only basic research but also the development of novel diagnostic and therapeutic tools. The pursuit of knowledge regarding aldolase has far-reaching implications for human health and biotechnology.
"Aldolase Quest: A Deep Dive into Enzyme Function and Clinical Significance" – Detailed Outline:
I. Introduction: Hooking the reader with the importance and intrigue of aldolase. Briefly outlining the article's scope and purpose.
II. Understanding Aldolase:
A. Structure and Function: Detailed explanation of the enzyme's catalytic mechanism and its role in glycolysis.
B. Isozymes: Discussion of the different aldolase isozymes (A, B, C), their tissue distribution, and functional differences.
C. Regulation: Exploration of the factors that regulate aldolase activity.
III. Aldolase in Clinical Diagnostics:
A. Biomarker for Muscle Damage: Explanation of how elevated aldolase levels indicate muscle injury.
B. Biomarker for Liver Disease: Discussion of aldolase as an indicator of hepatic dysfunction.
C. Limitations and Interpretations: Highlighting the importance of considering aldolase levels alongside other clinical data.
IV. Aldolase in Research:
A. Enzyme Engineering: Exploring the potential for modifying aldolase for biotechnological applications.
B. Drug Development: Discussing aldolase as a potential target for therapeutic interventions.
C. Advanced Diagnostic Tools: Examining advancements in using aldolase for improved diagnostic capabilities.
V. Conclusion: Summarizing key findings and emphasizing the ongoing importance of "Aldolase Quest."
(The following sections would then expand on each point in the outline, providing detailed explanations and incorporating relevant scientific information. Due to the length constraints of this response, I am unable to fully flesh out each section. However, the outline provides a solid framework for a 1500+ word article.)
Frequently Asked Questions (FAQs)
1. What is the primary function of aldolase? Aldolase catalyzes the cleavage of fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, a crucial step in glycolysis.
2. What are the different types of aldolase isozymes? The major isozymes are aldolase A (muscle), aldolase B (liver), and aldolase C (brain).
3. How is aldolase used in clinical diagnostics? Elevated aldolase levels in blood can indicate muscle damage (rhabdomyolysis, muscular dystrophy) or liver damage.
4. What are the limitations of using aldolase as a diagnostic marker? Aldolase levels alone are not diagnostic; they must be considered with other clinical and lab findings.
5. What is the role of aldolase in glycolysis? It catalyzes a key reversible step, splitting a six-carbon sugar into two three-carbon molecules.
6. How is aldolase regulated? Its activity is influenced by factors such as substrate availability, pH, and allosteric regulation.
7. What are the potential therapeutic applications of aldolase? Research explores its potential as a drug target for cancer and metabolic disorders.
8. What are current research trends in aldolase studies? Focus is on enzyme engineering, drug development targeting aldolase, and developing improved diagnostic tests.
9. Where can I find more information on aldolase research? PubMed, scientific journals, and university research databases are good starting points.
Related Articles:
1. Glycolysis and Energy Production: A detailed explanation of the glycolytic pathway and its importance in energy metabolism.
2. Muscle Disorders and Biomarkers: An overview of muscle diseases and the role of various biomarkers in diagnosis and monitoring.
3. Liver Function Tests and Interpretation: A guide to interpreting liver function tests, including aldolase levels.
4. Enzyme Kinetics and Catalysis: An in-depth look at enzyme mechanisms and factors affecting enzyme activity.
5. Metabolic Pathways and Regulation: A comprehensive overview of various metabolic pathways and their regulation.
6. Biomarker Discovery and Development: Discussion on the process of identifying and validating novel biomarkers for disease.
7. Advanced Enzyme Engineering Techniques: An exploration of methods used to modify and improve enzyme properties.
8. Drug Target Identification and Validation: A guide to identifying and validating potential drug targets.
9. The Role of Enzymes in Human Health: A broad overview of the significance of enzymes in various physiological processes.
| aldolase quest: Phenotyping at plant and cell levels: The quest for tolerant crop development Ulrich Schurr, Estelle Goulas, Carla Pinheiro, Sebastien Christian Carpentier, Dionysia Apostolos Fasoula, Astrid Junker, 2024-02-05 |
| aldolase quest: Phenotyping at Plant and Cell Levels: The Quest for Tolerant Crop Development, volume II Ulrich Schurr, Carla Pinheiro, Dionysia Apostolos Fasoula, Estelle Goulas, Sebastien Christian Carpentier, Astrid Junker, 2023-11-22 This Research Topic is part of the Phenotyping at Plant and Cell Levels: The Quest for Tolerant Crop Development series: Phenotyping at Plant and Cell Levels: The Quest for Tolerant Crop Development This Research Topic aims at accelerating the discovery of crop varieties that are able to withstand environmental stresses, via the use of phenotyping approaches at the plant and cellular levels. Climate change is expected to have a drastic impact on agriculture, notably by impacting water availability, precipitations, temperatures, soil nutrients, and the incidence of diseases and pests. A better use of plant genetic resources and plant breeding are key to tackling this challenge from climate change and for food security. Many landraces and wild relatives of crops are conserved in seed and gene banks. These collections are potentially valuable for breeders, but are presently underexploited. Moreover, the contribution of the soil microbiome to enhance the performance of specific plant genotypes has been overlooked. The aim is to generate crops that are resistant against biotic stress or can tolerate abiotic stress without significant impact on their performance. Current studies in the field of sensor technologies and phenomics are mainly empirically based and do not link the phenotypic parameters to the molecular scale. Similarly, many molecular studies do not correlate their findings to the whole plant phenotype. The quantitative high throughput analysis of crop potential and behavior during stress is a form of Genotype x Environment interaction and is a major bottleneck. We urgently need to identify resilient genotypes and to understand the underlying mechanisms of this resilience. Phenotyping science is quickly developing to characterize plant behavior, it's dynamic dimensions, and to quantify features such as growth and stress resilience, which increasingly permit to link the phenotype to genetic control. |
| aldolase quest: The Quest for Food Harald Brüssow, 2007-06-01 This book explores the links between food and human cultural and physical evolution. Each chapter begins by summarizing the basic knowledge in the field, discusses recent research results, and confirms or challenges established concepts, inviting new insight and provoking new questions. This book catalyzes discussion between scientists working on one side in food science and on the other side in biological and biomedical research. |
| aldolase quest: Clinical Laboratory Reference , 2007 Laboratory products and services currently available in the United States. Product information section arranged alphabetically by companies. Entries include description and ordering information. Indexes by manufactures; brand names; and test, equipment, and services. Product photograph section. |
| aldolase quest: Longevity, a Quest Johan Bjorksten, 1981 |
| aldolase quest: Calixarenes C David Gutsche, 2008-01-22 Calixarenes was the first book to be published in the `Monographs in Supramolecular Chemistry' series and is also the first complete survey available of this rapidly developing field. It provides a fascinating and lively account of the history, development and applications of calixarenes, which are probably the world's most readily available synthetic molecular baskets. These basket shaped compounds possess the ability to hold metal ions, as well as molecules, in their interior and as a result of their extraordinarily easy synthesis from phenols and aldehydes are receiving increasingly wide attention. This book is a must for advanced undergraduates and post-graduates studying bio-organic and supramolecular chemistry. |
| aldolase quest: Reports , 1965 |
| aldolase quest: Chemistry and Biology of Pteridines and Folates Sheldon Milstien, Gregory Kapatos, Robert A. Levine, Barry Shane, 2012-12-06 Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects. Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information. |
| aldolase quest: Prediction of Protein Structure and the Principles of Protein Conformation G.D. Fasman, 2012-12-06 The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged. |
| aldolase quest: Photosynthesis in Action Alexander Ruban, Christine Foyer, Erik Murchie, 2022-01-12 Photosynthesis in Action examines the molecular mechanisms, adaptations and improvements of photosynthesis. With a strong focus on the latest research and advances, the book also analyzes the impact the process has on the biosphere and the effect of global climate change. Fundamental topics such as harvesting light, the transport of electronics and fixing carbon are discussed. The book also reviews the latest research on how abiotic stresses affect these key processes as well as how to improve each of them. This title explains how the process is flexible in adaptations and how it can be engineered to be made more effective. End users will be able to see the significance and potential of the processes of photosynthesis. Edited by renowned experts with leading contributors, this is an essential read for students and researchers interested in photosynthesis, plant science, plant physiology and climate change. - Provides essential information on the complex sequence of photosynthetic energy transduction and carbon fixation - Covers fundamental concepts and the latest advances in research, as well as real-world case studies - Offers the mechanisms of the main steps of photosynthesis together with how to make improvements in these steps - Edited by renowned experts in the field - Presents a user-friendly layout, with templated elements throughout to highlight key learnings in each chapter |
| aldolase quest: Hypoxia in Cancer: Significance and Impact on Cancer Therapy Sukhes Mukherjee, Jagat Rakesh Kanwar, 2023-04-13 This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches. |
| aldolase quest: Advances in Helicobacter Research and Treatment: 2013 Edition , 2013-06-21 Advances in Helicobacter Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Helicobacter hepaticus. The editors have built Advances in Helicobacter Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Helicobacter hepaticus in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Helicobacter Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| aldolase quest: Carbon-13 NMR Spectroscopy of Biological Systems Nicolau Beckmann, 1995-04-06 This book is intended to provide an in-depth understanding of 13C NMR as a tool in biological research. 13C NMR has provided unique information concerning complex biological systems, from proteins and nucleic acids to animals and humans. The subjects addressed include multidimensional heteronuclear techniques for structural studies of molecules in the liquid and solid states, the investigation of interactions in model membranes, the elucidation of metabolic pathwaysin vitro and in vivo on animals, and noninvasive metabolic studies performed on humans. The book is a unique mix of NMR methods and biological applications which makes it a convenient reference for those interested in research in this interdisciplinary area of physics, chemistry, biology, and medicine. - An interdisciplinary text with emphasis on both 13C NMR methodology and the relevant biological and biomedical issues - State-of-the-art 13C NMR techniques are described; Whenever possible, their advantages over other approaches are emphasized - The chapters constitute comprehensive reviews and are written by acknowledged experts in their fields - Chapters are written in a clear style, and include a large number of illustrations and comprehensive references |
| aldolase quest: Principles of Genetics and Molecular Epidemiology Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, 2022-01-28 This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice. |
| aldolase quest: Structure in Protein Chemistry Jack Kyte, 2006-11-01 The second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces-ionic interactions, hydrogen bonding, and the hydrophobic effect-act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures. The latter include image reconstruction, nuclear magnetic resonance spectroscopy, proton exchange, optical spectroscopy, electrophoresis, covalent cross-linking, chemical modification, immunochemistry, hydrodynamics, and the scattering of light, X-radiation, and neutrons. These procedures are applied to study the folding of polypeptides and the assembly of oligomers. Biological membranes and their proteins are also discussed. Structure in Protein Chemistry, Second Edition, bridges the gap between introductory biophysical chemistry courses and research literature. It serves as a comprehensive textbook for advanced undergraduates and graduate students in biochemistry, biophysics, and structural and molecular biology. Professionals engaged in chemical, biochemical, and molecular biological research will find it a useful reference. |
| aldolase quest: Microbial Biotechnology Alexander N. Glazer, Hiroshi Nikaido, 2007-10-01 Knowledge in microbiology is growing exponentially through the determination of genomic sequences of hundreds of microorganisms and the invention of new technologies such as genomics, transcriptomics, and proteomics, to deal with this avalanche of information. These genomic data are now exploited in thousands of applications, ranging from those in medicine, agriculture, organic chemistry, public health, biomass conversion, to biomining. Microbial Biotechnology. Fundamentals of Applied Microbiology focuses on uses of major societal importance, enabling an in-depth analysis of these critically important applications. Some, such as wastewater treatment, have changed only modestly over time, others, such as directed molecular evolution, or 'green' chemistry, are as current as today's headlines. This fully revised second edition provides an exciting interdisciplinary journey through the rapidly changing landscape of discovery in microbial biotechnology. An ideal text for courses in applied microbiology and biotechnology courses, this book will also serve as an invaluable overview of recent advances in this field for professional life scientists and for the diverse community of other professionals with interests in biotechnology. |
| aldolase quest: Genomic Medicine Dhavendra Kumar, Charis Eng, 2014-10-15 Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008. |
| aldolase quest: Calixarenes in the Nanoworld Jacques Vicens, Jack Harrowfield, 2006-10-28 This book provides a timely review of both the current state of knowledge and the exciting prospects offered by calixarenes in nanotechnology. The book incorporates several review articles defining the importance of calixarenes as reagents in nanochemistry. Calixarenes in the Nanoworld is designed for a broad audience of professionals in universities, research institutions, and industries engaged in the production of high-tech materials. |
| aldolase quest: Enzymes in Food and Beverage Processing Muthusamy Chandrasekaran, 2015-10-23 Biotechnology, particularly eco-friendly enzyme technologies, has immense potential for the augmentation of diverse food products utilizing vast biodiversity, resolving environmental problems owing to waste disposal from food and beverage industries. In addition to introducing the basic concepts and fundamental principles of enzymes, Enzymes in Foo |
| aldolase quest: Gene Expression and Carcinogenesis in Cultured Liver L. E. Gerschenson, Edward Brad Thompson, 1975 |
| aldolase quest: Yeast Sugar Metabolism Friedrich K. Zimmermann, Karl-Dieter Entian, 2024-11-01 Yeast Sugar Metabolism looks at the biomechanics, genetics, biotechnology and applications of yeast sugar. The yeast Saccharomyces cereisiae has played a central role in the evolution of microbiology biochemistry and genetics, in addition to its use of a technical microbe for the production of alcoholic beverages and leavening of dough. |
| aldolase quest: Phlebotomy Essentials Ruth E. McCall, Cathee M. Tankersley, 2008 Thoroughly updated and enhanced by new print and electronic ancillaries, this full-color text provides accurate, practical information and instruction on phlebotomy procedures with a comprehensive background in theory and principles. Reflecting current CLSI guidelines, NAACLS competencies, and federal regulations, this Fourth Edition includes updated information on safety issues and equipment, laboratory information systems and instrumentation, legal issues, and diagnostic tests. This edition also includes caution notes identifying dangerous practices and problem areas. An accompanying CD-ROM includes clinical procedures videos, animations, electronic flashcards, and a glossary with audio pronunciations. Other ancillaries include a new companion Workbook, an Instructor's Resource CD-ROM, and online resources at thePoint. |
| aldolase quest: Cumulated Index Medicus , 1965 |
| aldolase quest: Physical Principles and Techniques of Protein Chemistry Part C Sydney Leach, 2012-12-02 Physical Principles and Techniques of Protein Chemistry, Part C focuses on the effects of intermolecular interactions that are transmitted between ligands and proteins and from protein to protein. This book discusses the density and volume change measurements; direct volume change; osmotic pressure; and small-angle X-ray scattering. The theory of particulate scattering; pulsed nuclear magnetic resonance; absorption of water by diamagnetic molecules; and use of least squares in data analysis are also elaborated. This text likewise covers the iteration process; optical rotatory dispersion and the main chain conformation of proteins; and basic relations for optically active molecules. Other topics include the circular dichroism, secondary structure of proteins, visible rotatory dispersion, and peptide cotton effects. This publication is intended for protein chemists, but is also useful to biologists, medical practitioners, and students researching on protein chemistry. |
| aldolase quest: Mineral Nutrition of Higher Plants Horst Marschner, 1995-04-11 An understanding of the mineral nutrition of plants is of fundamental importance in both basic and applied plant sciences. The Second Edition of this book retains the aim of the first in presenting the principles of mineral nutrition in the light of current advances.This volume retains the structure of the first edition, being divided into two parts: Nutritional Physiology and Soil-Plant Relationships. In Part I, more emphasis has been placed on root-shoot interactions, stress physiology, water relations, and functions of micronutrients. In view of the worldwide increasing interest in plant-soil interactions, Part II has been considerably altered and extended, particularly on the effects of external and interal factors on root growth and chapter 15 on the root-soil interface.The second edition will be invaluable to both advanced students and researchers.Key Features* Second Edition of this established text* Structure of the book remains the same* 50% of the reference and 50% of the figures and tables have been replaced* Whole of the text has been revised* Coverage of plant (soil interactions has been increased considerably) |
| aldolase quest: Travel Medicine E-Book Jay S. Keystone, David O Freedman, Phyllis E. Kozarsky, Bradley A. Connor, Hans D. Nothdurft, 2012-11-11 Travel Medicine, 3rd Edition, by Dr. Jay S. Keystone, Dr. Phyllis E. Kozarsky, Dr. David O. Freedman, Dr. Hans D. Nothdruft, and Dr. Bradley A. Connor, prepares you and your patients for any travel-related illness they may encounter. Consult this one-stop resource for best practices on everything from immunizations and pre-travel advice to essential post-travel screening. From domestic cruises to far-flung destinations, this highly regarded guide offers a wealth of practical guidance on all aspects of travel medicine. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Benefit from the advice of international experts on the full range of travel-related illnesses, including cruise travel, bird flu, SARS, traveler’s diarrhea, malaria, environmental problems, and much more. Prepare for the travel medicine examination with convenient cross references for the ISTM body of knowledge to specific chapters and/or passages in the book. Effectively protect your patients before they travel with new information on immunizations and emerging and re-emerging disease strains, including traveler's thrombosis. Update your knowledge of remote destinations and the unique perils they present. Stay abreast of best practices for key patient populations, with new chapters on the migrant patient, humanitarian aid workers, medical tourism, and mass gatherings, as well as updated information on pediatric and adolescent patients. |
| aldolase quest: Biocatalysis in Asymmetric Synthesis Gonzalo De Gonzalo, Andrés R. Alcántara, 2024-05-04 Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products. - Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction media - Features both foundational overviews and applied, practical examples across research and industry - Includes chapter contributions from international leaders in the field |
| aldolase quest: Exercise Physiology Tudor Hale, 2004-07-02 Exercise Physiology: A Thematic Approach introduces students with little or no background in human biology to the fundamentals of the physiological processes involved in sports performance. Its central theme is the physiological explanation of maximal oxygen uptake, one of the key concepts in sport and exercise physiology courses. It also includes material on anaerobic metabolism, carbon dioxide excretion and some special cases such as oxygen uptake at altitude and in a variety of extreme climates. Clearly written to provides a logical, linear development of the key concepts. Maximises the use of student's practical laboratory experiences. Includes numerous sporting examples to which students can relate. Excellent pedagogy including learning objectives, problems, objective tests and a glossary of terms and symbols. This is the first title in an exciting new series of Sports Science textbooks - Wiley SportTexts. It aims to provide textbooks covering the key disciplines within the academic study of sport. The series adopts a student-centred, interactive, problem-solving approach with the students’ immediate practical experience as the starting point. |
| aldolase quest: The Organization of Cell Metabolism G. Rickey Welch, James S. Clegg, 2012-12-06 |
| aldolase quest: Index Medicus , 2004 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| aldolase quest: Mechanisms in Duchenne Muscular Dystrophy Pathophysiology and Treatment Atsushi Asakura, Masatoshi Suzuki, Katsumasa Goto, 2023-09-07 |
| aldolase quest: Frontiers in the Chemical Sciences William Spindel, Robert Michael Simon, 1986 |
| aldolase quest: Medical Biotechnology, Biopharmaceutics, Forensic Science and Bioinformatics Hajiya Mairo Inuwa, Ifeoma Maureen Ezeonu, Charles Oluwaseun Adetunji, Emmanuel Olufemi Ekundayo, Abubakar Gidado, Abdulrazak B. Ibrahim, Benjamin Ewa Ubi, 2022-05-10 This book covers a range of topics on exploiting Nigeria’s mega biodiversity for food security and health; DNA forensic science and its applications; medical biotechnology and biopharmaceutics; medicinal and underutilized plants; impact and mitigation of antibiotic resistance; bioinformatics applications; medical insect biotechnology; etc. The book will be useful reference material for the scientists and researchers working in the fields of nutraceuticals, molecular diagnostics and DNA forensics, biopharmaceuticals and medical biotechnology, nanotechnology, antimicrobials from indigenous plant species, bioinformatics, etc. Emphasizes recent advances in biotechnologies that will help in tackling emerging global health challenges Provides detailed information on how to harness indigenous bioresources including microorganisms and plants for healthcare delivery Introduces new frontiers in the areas of molecular diagnostics and DNA forensic science and bioinformatics with case studies, recent advances in medical insect biotechnology and molecular genetics of pest use towards the exploitation of arthropod midgut components to develop interventions against infectious diseases Reviews bioactive molecules derived from commonly used and underutilized medicinal plants that could be used to develop novel drugs for improved healthcare delivery Discusses current approaches in medical and biopharmaceutical biotechnology, deployment of inexpensive genomics-based vector surveillance for effective disease outbreak prediction and control of mosquito-borne viruses Hajiya Mairo Inuwa, Ph.D., is Professor in the Department of Biochemistry and Formerly Director, Centre for Biotechnology Research and Training (CBR&T), Ahmadu Bello University, Zaria, Nigeria. Ifeoma Maureen Ezeonu, Ph.D., is Professor of Medical Microbiology and Molecular Genetics in the Department of Microbiology, University of Nigeria, Nsukka, Nigeria. Charles Oluwaseun Adetunji, Ph.D., is Associate Professor of Microbiology and Biotechnology and Director of Intellectual Property and Technology Transfer, Edo State University, Uzairue, Nigeria. Abubakar Gidado, Ph.D., is Professor of Biochemistry and Director of North-East Zonal Biotechnology Centre of Excellence at the University of Maiduguri. Emmanuel Olufemi Ekundayo, Ph.D., is Associate Professor of Medical Microbiology and Microbial Genetics, Michael Okpara University of Agriculture, Umudike, Nigeria. Abdulrazak B. Ibrahim, Ph.D., is a Capacity Development Expert at the Forum for Agricultural Research in Africa (FARA) and Associate Professor of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. Benjamin Ewa Ubi, Ph.D., is a Professor of Plant Breeding and Biotechnology and Director, Biotechnology Research and Development Centre, Ebonyi State University, Abakaliki, Nigeria. |
| aldolase quest: Bioenergetics of the Cell: Quantitative Aspects Valdur A. Saks, Renée Ventura-Clapier, Xavier Leverve, André Rossi, Michel Rigoulet, 2012-12-06 This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation. |
| aldolase quest: Nanozymes: Next Wave of Artificial Enzymes Xiaoyu Wang, Wenjing Guo, Yihui Hu, Jiangjiexing Wu, Hui Wei, 2016-07-27 This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis. |
| aldolase quest: 4th Applied Synthetic Biology in Europe Jean Marie François, Fayza Daboussi, Jussi Jantti, 2020-06-29 |
| aldolase quest: Medical Subject Headings National Library of Medicine (U.S.), 1995 |
| aldolase quest: An Infectious Origin of Alzheimer’s Disease: An End for This Devastating Disorder? Judith Miklossy, Rudolph Tanzi, Kilmer McCully, George Perry, Carl Cotman, StJohn Crean, Matthew Richard Chapman, Tamas Fulop, Patrick McGeer, Robert David Moir, Herbert B. Allen, 2020-08-10 |
| aldolase quest: Australian Journal of Chemistry , 2004 |
| aldolase quest: Chemical Abstracts , 1990 |
